Does Egg Freezing or Donation Cause Early Menopause? An OB/GYN's Perspective

If you're considering egg freezing or donation and are just curious about its long-term effects, you may have heard a rumor: "Does egg donation cause early menopause?" It's a valid question, and in this article I will break it down for you with the latest scientific information and my professional insights as a board-certified OB/GYN.

I have guided countless patients considering egg freezing and donation processes, and I understand the importance of addressing these concerns head-on. After all, your reproductive health is a big deal, and you deserve clear, accurate information to help you make informed decisions.

In this article, I’ll explain the science behind egg freezing and donation, explore common misconceptions, and look at what the research really says about its impact on your future fertility. I'll also share some insights on what actually influences the timing of menopause and offer tips on how to take care of your reproductive health. Alright, let’s go!

The short answer

Let's start with the good news: No, neither egg freezing nor egg donation causes early menopause, also known as premature ovarian insufficiency (POI). But I know you're looking for more than just a simple "no." You want to understand why, how we know this, and what these processes actually do to your body. So let’s go even deeper.

Understanding your ovaries and egg supply (aka ovarian reserve)

Before we get into the specifics of egg freezing and donation, let's refresh our understanding of how ovaries work. You were born with all the eggs you'll ever have – about 1-2 million of them! By the time you hit puberty, that number has already decreased to about 300,000-500,000. Throughout your reproductive years, you'll typically release one egg per month during ovulation.

Your body is constantly losing eggs, whether you're trying to get pregnant, on birth control, or not thinking about fertility at all. It's a natural process called atresia. Each month, several eggs begin to mature, but usually only one reaches full maturity and is released during ovulation. The rest are reabsorbed by the body.

What happens during egg freezing and donation?

When you freeze your eggs or donate them, you're given hormones to stimulate your ovaries to mature multiple eggs in a single cycle – typically anywhere from 10 to 20 eggs. These are eggs that would have otherwise been lost to the natural process of atresia. We're not dipping into some secret egg reserve or using up eggs that your body was "saving" for later.

The main difference between egg freezing and donation is what happens to the eggs after they're retrieved. With egg freezing, they're stored for your future use. With donation, they're provided to someone else who needs them to build their family. And with an egg sharing program like we offer at Cofertility, you keep and store half of your eggs retrieved for up to 10 years for free when you donate the other half to a family who can’t conceive otherwise.

Why the misconception exists

So, if the science is clear, why does this myth persist? There are a few reasons:

• Misunderstanding of ovarian stimulation: The process of stimulating multiple eggs to mature at once can sound unnatural, leading some to worry it's "using up" eggs too quickly.
• Confusion with natural fertility decline: As we age, our fertility naturally declines. Both the quantity and quality of our eggs decreases. Some people might attribute this normal process to their past egg freezing or donation.
• Individual variations: Someone who froze or donated eggs might experience fertility issues later, but this isn't necessarily caused by the procedure. Remember, 1 in 6 people are affected by infertility, whether they froze their eggs or not.
• Lack of long-term studies: While we have good medium-term data, very long-term studies (30+ years) are still ongoing. This can lead to uncertainty for some people.

What egg freezing and donation actually do to your body

Okay, so if these procedures don't cause early menopause, what do they actually do to your body? Let's break it down. During the stimulation cycle, you'll experience short-term hormonal changes, with higher levels of some hormones circulating in your system. This can lead to symptoms like bloating, mood swings, and breast tenderness – similar to what you might experience during your menstrual cycle, just more pronounced. These effects are temporary and typically subside after the egg retrieval process.

I break down all of the side effects and risks of egg freezing here. 

The medications used in egg freezing and donation will temporarily override your natural menstrual cycle. This is a necessary part of the process to stimulate multiple eggs to develop. After the egg retrieval, it usually takes about 1-2 months for your cycle to return to its normal rhythm. During this time, you might experience some irregularity in your periods, but this is generally nothing to be concerned about.

There is a minor risk of complications, primarily ovarian hyperstimulation syndrome (OHSS), where the ovaries become swollen and painful. However, serious cases of OHSS are rare, especially with modern protocols and careful monitoring throughout the process. Your medical team will be vigilant in watching for any signs of OHSS and can adjust your treatment if necessary.

Perhaps most importantly, current evidence shows no significant long-term impact on your fertility or the timing of menopause from egg freezing or donation procedures. Your body continues its natural reproductive processes after these procedures, and your remaining eggs are unaffected. This means that your future fertility and the onset of menopause should follow their natural course, just as they would have without the egg freezing or donation process.

Factors that actually influence menopause timing

Now that we've cleared up the egg freezing and donation myth, let's talk about what really can influence when you'll hit menopause:

1. Genetics: The age your mother went through menopause is a good indicator of when you might do so.
2. Your period: The age when you had your first period can influence the timing of menopause, especially if you got your first period before age 11. So can an irregular menstrual cycle.
3. Number of pregnancies: Compared to those who had never been pregnant or who had been pregnant for less than six months, women who had one full-term pregnancy had an 8% lower risk of early menopause. Those who had two pregnancies had a 16% lower risk, and those who had three pregnancies had a 22% lower risk.
4. Lifestyle factors: The use of tobacco and alcohol, as well as your level of physical activity, can influence when menopause occurs.
5. Medical history: Procedures that remove your ovaries or uterus can affect menopause timing. So too can autoimmune diseases.
6. Diet: Your diet, particularly the consumption of polyunsaturated fats, may have an effect.

Notice that egg freezing and donation aren't on this list!

Taking care of your fertility

Whether you're considering egg freezing, donation, or neither, there are several important steps you can take to support your reproductive health. First and foremost, regular check-ups are key. Keeping up with your gynecological exams allows you to stay on top of your reproductive health and provides opportunities to discuss any concerns with your doctor. These regular visits can help catch potential issues early and ensure you're taking the best possible care of your reproductive system.

Adopting a healthy lifestyle is another key aspect of maintaining your fertility. This includes eating a balanced diet rich in nutrients that support reproductive health, exercising regularly to maintain a healthy weight and promote overall well-being, and avoiding harmful habits like smoking. These lifestyle choices not only benefit your reproductive health but also contribute to your overall health and longevity.

If you're concerned about your future fertility, considering options like egg freezing can be a proactive step. At Cofertility, we understand the importance of having options when it comes to your reproductive future. 

• Through our Split program, qualified freezers can freeze their eggs for free when donating half of the eggs retrieved to a family who can’t otherwise conceive.
• Through our Keep program — where you keep 100% of eggs retrieved for your own future use — we offer exclusive discounts on expenses, such as frozen egg storage. Keep members also still gain free access to our Freeze by Co Community, a safe space for those engaging in the egg freezing process (or gearing up for it) to connect and lean on each other.

By making egg freezing easier and more accessible, our programs further strengthen the American Society of Reproductive Medicine (ASRM)’s Committee Opinion that egg freezing can help promote social justice and strengthen gender equality.

Final thoughts

So, there you have it – the long and short of egg freezing, egg donation, and menopause. The bottom line is that current scientific evidence does not support the idea that these procedures cause early menopause. Your body is incredibly resilient, and these processes work within your natural reproductive system, not against it.

That being said, egg freezing and donation are still significant medical procedures. It's important to work with reputable clinics (like our partner clinics!) that prioritize your health and provide comprehensive information.

Understanding your body and your options is key to making informed decisions about your reproductive health. Whether you're considering egg freezing, thinking about donation, or just curious about how it all works, I hope this information has been helpful.

If you have more questions about egg freezing, donation, or reproductive health in general, don't hesitate to reach out. At Cofertility, we're here to support you every step of the way on your fertility journey.

Read more:

• What are the Side Effects and Risks of Egg Freezing?
• Does Donating Eggs Affect Your Fertility?
• What’s the Best Age to Freeze My Eggs?