Should I Expect Side Effects When Taking Progesterone for IVF?

Progesterone Side Effets IVF

As if you’re not being poked, prodded and dosed up enough during the whole IVF process, your doctor might prescribe some progesterone for good measure. So what you want to know is, how bad is this going to be, really? We’ve got answers about progesterone during IVF, including its side effects (and hopefully it won’t be so bad). So here goes.

The whole point of the extra meds

Progesterone is a sex hormone that exists in the body. It does a lot of things, but in essence, it’s necessary for a healthy pregnancy, most notably because it helps get the uterine lining (the endometrium) ready for an embryo to make a home there.

For IVFers, progesterone might be prescribed in addition to the usual injections. You probably already know that your injections—a.k.a. gonadotropins such as Follistim, Gonal-F, Pregnyl, Repronex, etc.—help you ovulate. Progesterone, however, is taken later, often starting the same day the eggs are retrieved during a fresh cycle.

According to Dr. David Diaz, MD, reproductive endocrinologist at MemorialCare Orange Coast Medical Center in Fountain Valley, California, progesterone supports the lining of the uterus, which helps during embryo implantation. Implantation is what you want—that embryo needs to “stick” to the uterine wall, so you can officially get pregnant and stay that way.

The nitty gritty on taking progesterone

Don’t kill the messenger, but although some clinics will prescribe progesterone orally, you’re likely going to have to take this drug through one of two not-so-fun ways:

  • Shots: For IVF, progesterone can be taken via intramuscular injection. By intramuscular, we mean in your butt cheek, or maybe a hip or thigh. The shot will contain the hormone, as well as a little bit of natural oil for dissolving purposes.
  • Vaginal capsules: Yep, a suppository inserted your lady parts could be an option for you if the shots are a no-go. “[The capsules] dissolve internally,” says Dr. Diaz.” They work well and provide a good alternative to patients unable to tolerate the injection or those allergic to the injectable form.” Basically you’ll insert it similar to how you would put in a tampon.

You’ll have to take progesterone according to doctor’s orders until you get your pregnancy test results. If you do get pregnant, your doctor may want you to continue taking progesterone throughout your first trimester, says the ASRM, since it may help prevent pregnancy loss.

Side effects of progesterone during IVF

Watch out for progesterone side effects during your IVF journey. Common side effects include:

For the shots

  • Pain at the injection site
  • Swelling at the injection side
  • Small knot in the muscle at the injection site

For the vaginal suppositories

  • Vaginal itching or burning
  • Yeast infection

For either

  • Dizziness or tiredness
  • Mood swings
  • Bloating
  • Nausea
  • Cramps

No matter how you’re taking your progesterone for IVF, you’ll want to notify your doc if you have serious or sudden side effects. According to the University of Michigan Medicine, this could include:

  • Signs of allergic reaction
  • Unusual vaginal bleeding
  • Pain or burning when you pee
  • Symptoms of depression
  • Lump in your breast
  • Sudden vision problems
  • Severe headache
  • Chest pain or pressure
  • Jaundice (yellow skin or eyes)
  • Sudden numbness or weakness
  • Sudden severe headache
  • Slurred speech
  • Other problems with speech or balance
  • Sudden cough or wheezing
  • Rapid breathing
  • Pain, swelling, warmth, or redness in one or both legs

Pro tips

None of this sounds like a walk in the park, but we do have some tips that can make the whole progesterone process a little easier.

If you’re doing shots

  • Have your partner or a trusted friend or family member help. This is not an easy solo feat.
  • Invest in both a heating pad and ice pack. “We recommend using a cold pack alternating with a warm pack to minimize discomfort,” says Dr. Diaz.
  • Switch injection sites. Shooting in the same place on the body will just cause more pain and possibly tissue damage.
  • Massage the muscle gently after injecting.

If you’re doing vaginal suppositories

  • Use an applicator if it came in your pack. But throw it away after use. (Reusing is just a hard no.)
  • For a PM dosage, insert it before bed, so gravity’s on your side.
  • Use panty liners, since you’ll probably have some oily discharge. (Ew.) You’ll thank us later for this tip.

Always take your meds according to the doctor’s or nurse’s instructions. If you’re doing progesterone shots, you’ll likely get a full run through of the whole process. Ask lots of questions about anything that’s confusing or weird.

And let’s hope that progesterone—no matter how you take it—helps this IVF stick. Good luck!

Elena Donovan Mauer

Elena Donovan Mauer is a writer and editor passionate about helping people through their fertility journey. She’s a former editor of The Bump and CafeMom and has written about fertility and pregnancy for Parents, Parenting and other publications.

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