First-Time vs Repeat Egg Donors: Which One Should I Pick?

Intended parents are often asking me if they should choose a first-time or proven egg donor. While it may initially seem like a major consideration, in reality, it often plays a relatively minor role in the overall process. In this article, I hope to clarify this question and guide you towards more consequential aspects in your decision-making process.

Understanding egg donation

Egg donation involves a woman donating her eggs to help another family conceive via in-vitro fertilization (IVF). These donated eggs are fertilized in a laboratory, and the resulting embryos are then transferred into the recipient's uterus or a gestational carrier. Most donors are first-time donors who have never donated before, but some are proven donors who have previously donated eggs which have resulted in successful pregnancies.

First-time vs. repeat egg donors

A first-time donor has no history of successful pregnancies, however this does not mean that she is not a wonderful donor. Even though it may provide some pause that the donor has not donated before, the number of eggs likely to be retrieved in a donation cycle can be predicted based on markers like anti-Mullerian hormone (AMH) levels and antral follicle count (AFC). These metrics provide solid indicators of ovarian reserve and, consequently, the potential success of an egg retrieval procedure.

On the other hand, proven donors have a track record of successful pregnancies through their donated eggs, which can offer some reassurance to intended parents going through egg donation. It’s another data point to give you confidence. However, a proven donor's history of successful pregnancies doesn't guarantee future success. Plus, a donor who has donated more than once means that your future child is more likely to have biological half-siblings. 

What matters most: family fit

As shared above, reliable estimates for the quantity of eggs that are likely to be retrieved during a donation cycle can be made based on biomarkers such as AMH and AMC. These critical measures serve as robust predictors of ovarian reserve and, therefore, help project the likely outcome of the egg retrieval process. A donor who has been medically cleared by a fertility doctor – whether she has donated before or not – has a good chance of a successful retrieval. In fact, donor egg IVF has better outcomes than other forms of ART.

Once an egg donor has been medically cleared, we think the "fit" of the donor with your family is arguably more critical. This fit might involve physical attributes, ethnicity, education, or other aspects that matter to you in relation to your future child. Donor profiles and interviews can provide valuable insights into these aspects, guiding your choice towards a donor who aligns with your vision for your family.

A downside of a “proven” donor: the biological half-sibling factor

A less commonly discussed aspect of using a proven donor is that your child may have biological half-siblings resulting from previous successful donations. While this fact doesn't influence the potential success of your IVF process, it's an important ethical and emotional consideration for many potential parents. For some, this potential genetic connection to other families might be concerning or undesirable. 

However, simply because a first time donor has not donated eggs before, it does not mean she will not potentially donate to other families in the future. This would also lead to biological half-siblings for your children. This is not something to be nervous or hesitant about though as it can be a beautiful thing. It has been seen that children born from the same donor sometimes seek each other out, and find family in the USA or around the world, and have stories to share between each other of being a donor conceived child. A very unique bond can be established between donor conceived children.

It's important to note that the possibility of having numerous genetic half-siblings doesn't inherently detract from the unique bond and relationship you will develop with your child. Yet, it's a factor to be aware of and something to consider based on your personal values and vision for your future family.

How many times can an egg donor donate?

There is a limit to how many times a woman can donate eggs, primarily based on ethical and safety guidelines. In the United States, for example, the American Society for Reproductive Medicine (ASRM) recommends that donors should not donate eggs more than six times during their lifetime. This guideline aims to minimize potential health risks for the donor and limit the number of offspring born from any one donor's eggs (although to be clear, even if a donor donates six times through an egg bank, those eggs could be distributed to far more than six families). At Cofertility, we follow these guidelines and actually find that most of our donors don’t plan on donating to more than one or two families because they are not doing it for cash compensation. 

Summing it up

Remember that while the choice of an egg donor is significant, it is just one aspect of the broader journey to parenthood. Other aspects, like ensuring the health of the mother or gestational carrier, preparing for the emotional and financial commitment of parenthood, and creating a nurturing environment for your child, are critical contributors to your child’s life.

While the decision between a first-time and proven egg donor can seem overwhelming, remember that this is just one factor among many in your fertility journey. Reliable fertility markers, such as AMH and AFC, offer significant predictors of egg retrieval success. Furthermore, the alignment of a donor with your vision of your future family is of paramount importance.

Each family's journey is unique, and there is no 'one size fits all' answer. Being patient with the process, staying informed, and leaning on the support of medical and mental health professionals can guide you towards the decisions that feel right for you and your family.

How Cofertility is different 

We started this company with the vision of serving all families, regardless of what brought them here. We promise to provide you with the care we would want for our families. With our commitment to transparency, inclusivity, and innovation, we are striving to be the best in the industry.

Our unique egg sharing model empowers donors and enables families to find the perfect egg donor match quickly and easily, setting a new standard for excellence in our field. Whether you are just becoming educated on egg donation or are ready to move forward, we want to help you achieve your goals and build the family of your dreams.

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