How to Increase Egg Freezing Chances of Success

More and more people in the US (and the rest of the world) are taking control of their reproductive health and fertility by choosing to freeze their eggs. Whether this is so they can focus on a career, get an insurance policy with coverage for treatments, or because of medical reasons, this has allowed people to delay having children until whenever they’re ready to start a family.

If you’re thinking about freezing your eggs, you probably have tons of questions. In this article, we’re going to focus on a very common question: “How can I increase my chances of success when I freeze my eggs?”

Factors that can affect egg freezing success rates

Before an egg freezing cycle

Let’s start by going through what specific things make a difference in your chances of success before you even freeze your eggs.

Age

Age has been proven by countless research studies to be one of the biggest determinants of egg quality. As a person ages, their eggs are more likely to become aneuploid, meaning they’re genetically “abnormal.” This can lead to issues with both getting and staying pregnant (i.e, higher risk of miscarriages). On top of that, as a person ages, the number of eggs their ovaries contain continues to decrease naturally. Once a person reaches their mid to late thirties, the quality and quantity of eggs starts to go down more quickly. While there is no “perfect” age at which to freeze your eggs, freezing them before you reach your late 30s is considered ideal. 

AMH level

Another important factor is your Anti-Müllerian hormone (AMH) level. This is a simple blood test that is commonly used to tell us a person’s reproductive potential based on the number and the quality of eggs they have left in their ovaries. AMH is released by antral follicles, which are small, fluid-filled sacs in the ovaries that each contain a single oocyte (immature egg). Your AMH level is positively correlated with the number of antral follicles you have in your ovaries. Simply stated, the more follicles you have, the higher your AMH level typically is. AMH naturally goes down as a person gets older until it reaches close to zero during perimenopause. While there is no international standard for what a normal AMH level is, some studies have tried to create models for what’s considered normal for specific ages. Check out this article to find out more about AMH levels at different ages.

Antral follicle count

Antral follicle count (AFC) is another number to be aware of before egg freezing. AFC is used in fertility assessments to estimate the number of developing follicles in someone’s ovaries at a specific point in the menstrual cycle using ultrasound. As mentioned before, the more follicles you have (the higher your AFC is), the higher your AMH level. And just like your AMH, your AFC will also naturally go down as you age. 

How these values affect your egg freezing success 

Unfortunately, there isn’t a lot that can be done about aging or about the decline in AMH and AFC that goes with it but there are a few things to know about how they affect your egg freezing changes. 

• Ovarian reserve assessment. Age, AMH and AFC all provide valuable information about a person’s ovarian reserve. In general, younger age, higher AMH levels, and a higher AFC are good indicators that you have a larger pool of potential eggs in the ovaries. This means that you’re more likely to produce more eggs during an egg retrieval cycle, which increases the chances of a successful egg freezing cycle.
• Response to ovarian stimulation. Part of the egg freezing cycle includes taking medications to stimulate the ovaries to develop multiple eggs at once (as opposed to just one during a natural, unmedicated menstrual cycle). The response to these medications can vary based on age, AMH, and AFC. People who are younger and those who have a higher AFC/AMH tend to have a better response and produce more mature eggs during the stimulation. This increases the chances of retrieving a larger number of high-quality eggs for freezing.
• Number of cycles. In some cases, people with a lower AFC and/or AMH may have to go through more than one egg freezing cycle in order to get an adequate number of eggs. This can get costly and time-consuming pretty quickly.
• Future fertility potential. The number and quality of frozen eggs affects the chances of having a successful pregnancy when the frozen eggs are later thawed, fertilized, and transferred during an in vitro fertilization (IVF) treatment. A higher AFC and AMH can mean a higher number of frozen eggs, which increases a person’s chances of success in the future. However, neither of these numbers is the end-all-be-all here. In fact, while AMH does seem to have some association with live birth rates after IVF, its ability to actually predict a live birth is not that great, especially for younger people.

Again, all three of these factors aren’t necessarily things you can change so it can be easy to get discouraged if your values aren’t where you want them to be. Remember that each of these is just one value your provider looks at to assess your overall reproductive potential. No value by itself can completely predict your chances of conceiving naturally or define your fertility. A comprehensive assessment of a person’s fertility potential has to be done by a fertility specialist before jumping to any conclusions and making decisions about fertility preservation.

During an egg freezing cycle

Now, let’s go through the factors during an egg freezing cycle that can affect your chances of success.

Quantity and quality of eggs retrieved

The success rates of egg freezing cycles are significantly influenced by both the number and quality of eggs retrieved. The number of eggs retrieved is important because it directly correlates with the chances of developing viable embryos after thawing. This is definitely a case of “more is more”--the more eggs that are successfully frozen, the higher the probability of having viable embryos when the time comes. 

However, the quality of the retrieved eggs is just as important. High-quality eggs have a better chance of surviving the freezing and thawing process than low-quality ones. So, as you can imagine, a cycle with lots of eggs that are all low-quality isn’t necessarily more successful than another cycle that produced less eggs but they’re all high-quality. 

As a result, fertility providers will always aim to maximize both the quantity and quality of the eggs retrieved. This is essential for improving  the success rates of egg freezing cycles so that, ultimately, we end up with healthier embryos and better chances of a successful pregnancy.

Type of freezing method used 

There are two main techniques used for freezing eggs: slow freezing and vitrification. The slow freezing method involves gradually lowering the temperature of the eggs, which allows ice crystals to form within the cells. This process can damage the delicate internal structure of the eggs, which can lead to lower viability and success rates once the eggs are thawed. In contrast, vitrification is a freezing process that solidifies the eggs quickly without forming ice crystals. This method protects the cell’s internal structures better and has been shown to increase post-thaw survival rates. This in turn, means higher success rates during IVF treatments. It makes complete sense, then, that vitrification has become the preferred way to freeze eggs.

Tips to increase egg freezing success rates

Alright, so now that we’ve established what’s important when it comes to egg freezing, what exactly can you do to maximize these factors for yourself? 

• Consider freezing your eggs at a younger age. There may not be much we can do about the fact that we’re all getting older but in terms of egg freezing, the general rule is that the younger you can do it, the better. According to the American Society for Reproductive Medicine (ASRM), the ideal time to freeze your eggs is in your 20s and early 30s, while you have more eggs and those eggs are healthier. So, whether you’re 25 or 35, your eggs today are still probably healthier than your eggs in one, five or 10 years!
• Optimize your fertility health before beginning the egg freezing process. This step will look a little different from person to person since everyone has their own unique medical history and concerns. Generally speaking though, optimizing your health will include following a balanced diet and making other healthy lifestyle choices. In some cases, you may want to consider adding certain vitamins and supplements to your regimen too. Make sure to talk to your fertility specialist if you’re not sure!
• Consider using a different type of freezing method. Ask your fertility provider which method they plan to use when freezing your eggs. Vitrification is the more common method now given its improved outcomes when compared to slow freezing but it doesn’t hurt to confirm that this is the method your particular clinic uses.   
• Consider doing multiple egg retrieval cycles. If you have the resources and time to do multiple cycles, this can vastly improve the pool of eggs to choose from in the future. This is an especially helpful option for people who are older or have a low AMH level or AFC. If your fertility provider thinks more cycles will improve your chances, they’ll discuss those recommendations with you.
• Be particular about the clinic you choose. There are a ton of fertility clinics to choose from nowadays, so take the time to do some detective work and find one that works for your needs. If you know people who’ve used a fertility clinic, ask them for their honest opinions. Read reviews. Look up the providers’ credentials (usually listed on the clinic’s website). You can also find out the clinic’s success rates in terms of live births and other important statistics through their website. Schedule a couple consultations to compare your options. Make sure to come with questions and to actually ask them all. If you’re not sure what to ask, check out some suggestions here. 

Emotional considerations

It’s important that we take a second to talk about the emotional side of this experience. For many people, the decision to freeze their eggs is tied to hopes of preserving future fertility. When a lab test or a cycle doesn't yield the desired results, there can be feelings of hopelessness, frustration, sadness, anxiety, and uncertainty about future family planning options. On top of that, this isn’t a cheap or simple process! So there can be disappointment stemming from both the financial and physical investments that have been made. 

Because of all of this, seeking support and guidance throughout this process has to be a priority. Support from both loved ones and through professional counseling can make a huge difference when it comes to coping with the emotions you might be dealing with. 

Establishing clear and open communication with your fertility providers also plays a key part in helping people cope with the challenges that might come up. Your providers know the ins and outs of your particular situation so they’re the most qualified to tell you what you need to prioritize (and what you can ignore) to improve the success of your egg freezing cycle(s).

With all the nuances involved here, it’s important not to get lost in the weeds. Fertility is impacted by so many factors that you can drive yourself crazy trying to manage all of them. Remember, you are more than any number. 

Conclusion

To recap, there are several different factors that can affect the success of an egg freezing cycle including your age, AMH level, AFC, the number and quality of eggs retrieved, and the type of freeing method used. Some of these, you don’t have control over. For the ones you can control, there are a few things you can do. 

Optimizing your fertility health before the egg freezing process, freezing your eggs at a younger age, doing more than one cycle, and using a safer freezing option are all ways that you can improve your chances of a successful freezing cycle. This process can be so overwhelming— focusing on the things that you can control can help you feel more grounded throughout your fertility journey. 

Freeze by Co is here to help you every step of the way on that journey. With our Keep program, you’re able to freeze your eggs and keep them all for yourself, on your timeline. In addition, you’ll have access to our online support community, the Nest. This is a valuable resource that lets you engage with other people freezing their eggs at the same time!